h Levels of Expression of Human Stromal Cell–Derived tor-1 Are Associated with Worse Prognosis in Patients

nloaded kground: Stromal cell–derived factor-1 (SDF-1) and its receptor, CXCR4, have been shown to mediate veness and metastatic behavior in a number of cancers, including ovarian, prostate, bladder, breast, and atic cancers. The expression and significance of SDF-1 in pancreatic ductal adenocarcinoma (PDA) ot been systematically studied. thods: We examined the expression of SDF-1 by immunohistochemistry using a mouse anti-human /CXCL12 antibody (dilution 1:300) and a tissue microarray consisting of 72 stage II PDAs from panoduodenectomy specimens. The staining results were categorized as SDF-1-high (SDF-1-H; cytoplasaining of ≥10% of tumor cells) or SDF-1-low (SDF-1-L; no staining or staining of <10% of tumor cells). sults of SDF-1 expression were correlated with clinicopathologic parameters and survival. Statistical es were done using SPSS software. ult: Of the 72 stage II PDAs, 25 (35%) showed high levels of SDF-1 expression. The median overall and ence-free survival for patients with SDF-1-H PDAs were 26.1 and 11.1 months, respectively, compared 4.3 and 22.3 months for patients with SDF-1-L tumors (log-rank test, P = 0.047 and P = 0.021). In multe analysis, high SDF-1 expression correlated with poor overall and disease-free survival (P = 0.02 and 02) independent of tumor size, differentiation, and lymph node status. clusion: High levels of SDF-1 expression were associated with poor overall and disease-free survival in ts with stage II PDA. SDF-1 may serve as a useful prognostic marker for stage II PDA. act:Our results suggest that SDF-1-CXCR4 or SDF-1-CXCR7 pathways may represent a potential target Imp for therapeutic intervention as well as prediction of prognosis in PDA. Cancer Epidemiol Biomarkers Prev; 19(10); 2598–604. ©2010 AACR.